IMMUNOHISTOCHEMISTRY, UROPLAKIN - II

What this test checks

Detects Uroplakin II, a protein specific to the lining cells of the urinary bladder. Used to confirm bladder cancer origin when a tumour has spread to other sites.

Why do people get this test?

Uroplakin II is one of the most specific markers for urothelial (bladder) cancer. Its presence in a tumour that has spread confirms bladder as the primary cancer site — directing treatment to bladder-cancer protocols.

When you should consider this test

• When cancer has spread and bladder cancer is the suspected primary
• When classifying metastatic carcinoma of unknown primary
• As part of urothelial cancer diagnostic panel

How to prepare

No preparation needed — performed on biopsy or surgical tissue.