IMMUNOHISTOCHEMISTRY, DESMIN

What this test checks

Detects desmin, a protein found in muscle cells. Used to identify tumours arising from muscle tissue (such as leiomyosarcoma and rhabdomyosarcoma) and confirm muscle differentiation.

Why do people get this test?

Desmin positivity confirms that a tumour has muscle cell characteristics — helping classify soft tissue tumours accurately so the correct treatment protocol is applied.

When you should consider this test

• When classifying soft tissue tumours
• When investigating a tumour suspected to arise from muscle
• As part of a soft tissue sarcoma diagnostic panel

How to prepare

No preparation needed — performed on biopsy or surgical tissue.