IMMUNOHISTOCHEMISTRY, CD 138

What this test checks

Detects CD138, a marker expressed on plasma cells. Used to confirm multiple myeloma (plasma cell cancer) and plasma cell neoplasms, and to identify plasma cell differentiation in other tumours.

Why do people get this test?

CD138 is essential for confirming plasma cell myeloma and related conditions. Accurate diagnosis ensures patients receive myeloma-specific treatments (proteasome inhibitors, IMiDs) rather than conventional lymphoma chemotherapy.

When you should consider this test

• When multiple myeloma or plasmacytoma is suspected
• When classifying a lymphoma or tumour with possible plasma cell differentiation
• As part of plasma cell neoplasm diagnostic panel

How to prepare

No preparation needed — performed on biopsy or bone marrow tissue.