IMMUNOHISTOCHEMISTRY, BCL-6

What this test checks

Detects BCL-6 protein, a transcription factor expressed in germinal centre B-cells. Used in lymphoma classification — particularly for identifying diffuse large B-cell lymphoma (DLBCL) subtypes and follicular lymphoma.

Why do people get this test?

BCL-6 is part of the 'Cell of Origin' classification for DLBCL, which determines prognosis and may guide treatment intensification. Correct lymphoma subtype identification is essential for choosing the right chemotherapy regimen.

When you should consider this test

• When classifying B-cell lymphomas
• When determining DLBCL subtype (GCB vs. non-GCB)
• As part of comprehensive lymphoma immunophenotyping panel

How to prepare

No preparation needed — performed on biopsy or surgical tissue.