HISTOPATHOLOGY SKIN BIOPSY PANEL WITH DIF

What this test checks

Examines skin tissue under both standard microscopy and immunofluorescence to diagnose autoimmune skin diseases — such as pemphigus, bullous pemphigoid, and lupus — that require special antibody staining to identify.

Why do people get this test?

Some skin diseases cannot be diagnosed by appearance alone. Direct immunofluorescence reveals the pattern of antibody deposits in the skin, giving a definitive diagnosis that guides immunosuppressive treatment.

When you should consider this test

• When you have blistering skin disease of unclear cause
• When autoimmune skin conditions like pemphigus or pemphigoid are suspected
• When a skin condition does not respond to standard treatments and a definitive diagnosis is needed

How to prepare

No preparation needed — the skin sample is taken by your dermatologist.